Nash (Don Johnson) is a smart-alecky police inspector, who's seen fighting crime on the streets of San Francisco, California, while driving around in his screaming yellow 1970ish Plymouth Hemi Barracuda. He's the typical super-cop on the beat, who always wins in the end. Unfortunately, his personal relationships leave much to be desired. He has two ex-wives, a sixteen-year-old daughter needing a lot of supervision, and a father with Alzheimer's disease who keeps getting kicked out of retirement homes and dropping by to visit.